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Precision Medicine in Bariatric Procedures.

Khushboo Gala¹, Wissam Ghusn², Andres Acosta³

¹Precision Medicine for Obesity Program, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55902, USA. Electronic address: https://twitter.com/KhushbooSGala.

Gastrointestinal Endoscopy Clinics of North America

|September 14, 2024

Summary

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This summary is machine-generated.

Precision medicine tailors obesity treatments using genetics, environment, and deep phenotyping for better results. This approach personalizes bariatric strategies for improved effectiveness and patient tolerance.

Area of Science:

Obesity research
Precision medicine
Bariatric science

Background:

Obesity is a complex disease with genetic, epigenetic, and environmental influences.
Current treatments often lack personalization, leading to variable outcomes.
Precision medicine offers a framework to address individual variability in obesity.

Purpose of the Study:

To review advances in precision medicine within the field of bariatrics.
To explore how individual variability can be leveraged for obesity treatment.
To discuss future directions and challenges in personalized obesity care.

Main Methods:

Deep phenotyping (clinical, physiological, behavioral characteristics).
Multi-omics assays (genomics, epigenomics, transcriptomics, microbiomics).

Keywords:

Bariatric endoscopy Bariatric surgery Epigenetics Genetics Obesity Precision medicine

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Integration of environmental factor data.

Main Results:

Personalized therapeutic strategies enhance treatment effectiveness.
Individualized approaches improve tolerability of interventions.
Precision medicine enables tailored prevention and treatment for obesity subsets.

Conclusions:

Precision medicine is transforming bariatric practice.
Integrating diverse data types is key to personalized obesity management.
Future research should address challenges in implementing precision bariatric strategies.