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Dual role of triglyceride structures facilitates anti-tumor drug delivery: Both as a self-assembling module and a

Wenxin Zhong1, Yalin Xu2, Zixuan Wang2

  • 1Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China; Joint International Research Laboratory of Intelligent Drug Delivery Systems, Ministry of Education, Shenyang, Liaoning 110016, China.

Journal of Colloid and Interface Science
|September 15, 2024
PubMed

Insights

Dual-responsive nanomedicines utilizing triglyceride and disulfide bonds show superior anti-tumor effects compared to single-responsive systems. This dual-response strategy enhances targeted drug delivery for small molecule prodrugs.

Area of Science:

  • Nanomedicine
  • Drug Delivery Systems
  • Prodrug Nanoparticles

Background:

  • Self-assembled nano-delivery systems using small molecule prodrugs with tumor-responsive linkages show promise for cancer therapy.
  • Tumor microenvironment heterogeneity can limit the efficacy of single-responsive prodrug nanomedicines.
  • Tumor cells often exhibit high levels of glutathione and lipase, presenting opportunities for targeted drug release.

Purpose of the Study:

  • To construct and evaluate single-responsive and dual-responsive prodrug nanoparticles for enhanced anti-tumor effects.
  • To investigate the role of triglyceride and disulfide bonds as response modules in nanomedicine.
  • To compare the anti-tumor efficacy of single-responsive versus dual-responsive prodrug nanoparticles.

Main Methods:

  • Development of a single-responsive prodrug nanoparticle using disulfide bonds as the response module and branched chain alcohol for self-assembly.
  • Construction of a dual-responsive paclitaxel prodrug nanoparticle by combining triglyceride and disulfide bonds.
  • Evaluation of the anti-tumor effects of both single-responsive and dual-responsive prodrug nanoparticles.

Main Results:

  • The single-responsive branched chain alcohol-modified prodrug nanoparticles exhibited inferior anti-tumor effects.
  • The triglyceride-based prodrug nanoparticles with dual response modules demonstrated superior anti-tumor efficacy.
  • Triglyceride structures function effectively as both self-assembly modules and tumor-responsive drug release triggers.

Conclusions:

  • Dual-responsive prodrug nanoparticles, particularly those incorporating triglyceride structures, offer enhanced anti-tumor effects compared to single-responsive systems.
  • The dual functionality of triglyceride structures (self-assembly and tumor-responsive release) facilitates efficient delivery of small molecule prodrugs to tumor sites.
  • This dual-response strategy holds significant potential for improving the efficacy of nanomedicines in cancer treatment.
Keywords:
ChemotherapyDual-responseNanomedicineProdrugSelf-assembly

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