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Updated: May 3, 2026

Synthesis and Catalytic Performance of Gold Intercalated in the Walls of Mesoporous Silica
Published on: July 9, 2015
In the search for new gold metalloantibiotics: In vitro evaluation of Au(III) (C^S)-cyclometallated complexes
Paula Pérez-Ramos1, Yaiza Gabasa2, Enmanuel Cornielle2
1Department of Organic and Inorganic Chemistry, University of Oviedo, Instituto Universitario de Química Organometálica Enrique Moles, C/ Julián Clavería 8, 33006 Oviedo, Spain.
Abstract:
A series of (C^S)-cyclometallated Au(III) cationic complexes of general formula [Au(dppta)(dtc)]+, [Au(dppta)(azmtd)]+ and [Au(dppta)(azc)Cl]+ (dppta = N,N-diisopropyl-P,P-diphenylphosphinothioic amide-κ2C,S; dtc = dithiocarbamate-κ2S,S'; azc = azolium-2-dithiocarboxylate-κ1S; azmdt = azol(in)ium-2-(methoxy)methanedithiol-κ2S,S') were synthetized and tested against a panel of bacterial strains belonging to different Gram-positive and Gram-negative species of the ESKAPE group of pathogens. Among the tested compounds, complex 4c had the higher Therapeutic Index (TI) against multidrug resistant strains of S. aureus, S. epidermidis and A. baumannii, showing a more favourable cytotoxicity profile than the reference gold metalloantibiotic Auranofin. © 2024 xxxxxxxx. Hosting by Elsevier B.V. All rights reserved.
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