Assessment of RNFL and macular changes in the eye related to multiple substance use using OCT

Substance use is a chronic and recurrent public healthcare concern increasing in the world, causing negative outcomes. Two or more substance use is common among people who have substance use disorders and who receive treatment. For this reason, the present study aimed to measure Retinal Nerve Fiber Layer (RNFL), Mean Macular Thickness (MMT), Central Macular Thickness (CMT) in patients who have Multiple substance use disorder (MSUD) using Optical Coherence Tomography (OCT), considering that it will contribute to the literature. Among the inpatients who were rehabilitated in Elazig Mental Hospital Alcohol and Substance Addiction Treatment Center, 75 people who were diagnosed with MSUD according to DSM-5 and met the criteria, and 51 control groups were included in the study. RNFL, MMT and CMT measurements of both eyes of all participants were made by using the OCT. Total RNFL measurement were significantly thicker than the control group (p < 0.001). MMT and CMT of the eyes of the patient were thinner than the control group (p = 0.009, p < 0.001). The findings provide important contributions to the literature data and in light of these findings, it can be recommended to consider visual findings and possible neurodegeneration when evaluating patients in the addiction group and planning their treatment.