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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
Targeting senescent cells in atherosclerosis: Pathways to novel therapies
Yuhan Tian1, Sihang Shao2, Haibo Feng3
1College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai-Tibet Plateau, Southwest Minzu University, Chengdu 610041, China.
Abstract:
Targeting senescent cells has recently emerged as a promising strategy for treating age-related diseases, such as atherosclerosis, which significantly contributes to global cardiovascular morbidity and mortality. This review elucidates the role of senescent cells in the development of atherosclerosis, including persistently damaging DNA, inducing oxidative stress and secreting pro-inflammatory factors known as the senescence-associated secretory phenotype. Therapeutic approaches targeting senescent cells to mitigate atherosclerosis are summarized in this review, which include the development of senotherapeutics and immunotherapies. These therapies are designed to either remove these cells or suppress their deleterious effects. These emerging therapies hold potential to decelerate or even alleviate the progression of AS, paving the way for new avenues in cardiovascular research and treatment.
Insights
Targeting senescent cells offers a new approach for age-related diseases like atherosclerosis. Therapies aim to remove or suppress these cells, potentially slowing cardiovascular disease progression.
Area of Science:
- Cardiovascular Research
- Cellular Senescence
- Immunology
Background:
- Atherosclerosis is a major cause of cardiovascular disease.
- Senescent cells contribute to atherosclerosis development.
- Senescence-associated secretory phenotype (SASP) promotes inflammation.
Purpose of the Study:
- To review the role of senescent cells in atherosclerosis.
- To summarize therapeutic strategies targeting senescent cells for atherosclerosis.
- To explore novel treatment avenues for cardiovascular disease.
Main Methods:
- Literature review on cellular senescence and atherosclerosis.
- Analysis of SASP mechanisms in disease progression.
- Summary of senotherapeutics and immunotherapies.
Main Results:
- Senescent cells promote atherosclerosis through DNA damage, oxidative stress, and SASP.
- Senotherapeutics and immunotherapies are emerging treatments.
- These therapies aim to eliminate senescent cells or mitigate SASP.
Conclusions:
- Targeting senescent cells is a promising strategy for atherosclerosis.
- Senolytics and immunotherapies may decelerate or alleviate cardiovascular disease.
- This approach opens new avenues in cardiovascular research and treatment.
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