Sensitive electrochemical detection of methimazole based on a unique copper and exfoliated graphene oxide...

Herein, we report the creation of a novel sensitive electrochemical sensing platform based on a copper and exfoliated graphene oxide (Cu-eGO) nanocomposite using a facile synthesis technique, which simultaneously removes the sodium ions that result from the exfoliation process to generate eGO from graphite. This novel Cu-eGO nanocomposite was characterized via SEM, EDX, Raman and XPS. The Cu-eGO/GCE exhibited much greater activity for the electrochemical oxidation of methimazole than the eGO/GCE or bare GCE. The electrochemical properties and kinetics involved in the oxidation of methimazole at the Cu-eGO were examined using voltammetry and electrochemical impedance spectroscopy (EIS). This Cu-eGO based sensing platform demonstrated high sensitivity at 1.32 μAμM^-1cm^-2, a low limit of detection at 0.06 μM, robust stability, and strong anti-interference against potential interferents that may exist in biological systems for the detection of methimazole. The developed electrochemical sensor was successfully employed in blood serum samples that mimicked real biological environments, showing its high applicability.