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MBV-Pipe: A One-Stop Toolbox for Assessing Mouse Brain Morphological Changes for Cross-Scale Studies.

Wentao Jiang1,2, Xinyi Liu1, Ming Song3,4

  • 1Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.

Neuroinformatics
|September 15, 2024
PubMed
Summary
This summary is machine-generated.

Mouse brain imaging reveals significant volume changes after perfusion, but white matter integrity remains stable. This study introduces MBV-Pipe, a new toolbox for analyzing mouse brain morphology during sample preparation.

Keywords:
Cross-scaleMRI data processingMorphologyMouse brainToolbox development

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Area of Science:

  • Neuroscience
  • Biomedical Imaging
  • Computational Biology

Background:

  • Mouse models are vital for neuroscience research.
  • Sample preparation for brain imaging can alter morphology, creating discrepancies.
  • Lack of accessible toolboxes hinders the assessment of mouse brain morphological changes.

Purpose of the Study:

  • To develop an accessible toolbox for processing mouse brain MRI data.
  • To assess morphological and white matter integrity changes during sample preparation.
  • To validate the reliability of the developed toolbox.

Main Methods:

  • Development of the Mouse Brain Volumetric Statistics-Pipeline (MBV-Pipe) toolbox.
  • Integration of Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra (DARTEL)-Voxel-based morphometry (VBM) and Tract-Based Spatial Statistics (TBSS).
  • Acquisition of mouse brain MRI data at three time points (in vivo, post-perfusion, post-fixation) using a 9.4T MRI system.

Main Results:

  • MBV-Pipe identified substantial volumetric changes post-perfusion compared to in vivo.
  • Fixation induced only minor volumetric variations.
  • White matter integrity remained largely stable across all preparation stages.

Conclusions:

  • MBV-Pipe reliably quantifies mouse brain morphological changes during sample preparation.
  • The toolbox aids in optimizing experimental protocols for mouse brain research.
  • MBV-Pipe is publicly available with a GUI, promoting wider adoption and reproducibility.