Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

59.7K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
59.7K
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

51
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
51
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

2.3K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.3K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

2.0K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.0K
Neural Regulation of Blood Pressure01:18

Neural Regulation of Blood Pressure

2.7K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.7K
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.4K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

4-anilinoquinoline triazines: a novel class of hybrid antimalarial agents.

European journal of medicinal chemistry·2011
Same author

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice.

The Journal of cell biology·2010
Same author

Buffalo hepcidin: characterization of cDNA and study of antimicrobial property.

Veterinary research communications·2010
Same author

High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome.

Journal of hepatology·2010
Same author

Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation.

Journal of immunology (Baltimore, Md. : 1950)·2010
Same author

Dlk1 is necessary for proper skeletal muscle development and regeneration.

PloS one·2010

Related Experiment Video

Updated: Jun 13, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

4.9K

The Baro-Adrenal Axis.

Sanjay Kalra1, Ashok Kumar2, Nitin Kapoor3

  • 1Department of Endocrinology, Bharti Hospital, Karnal, India University Center for Research & Development, Chandigarh University, India.

JPMA. the Journal of the Pakistan Medical Association
|September 16, 2024
PubMed
Summary
This summary is machine-generated.

The adrenal gland is part of the Ominous Octet contributing to obesity. The baro-adrenal axis highlights the complex relationship between weight regulation and adrenal function in health and disease.

Keywords:
Adrenal, Cushing’s syndrome, obesity, overweight, person centred care, pheochromocytoma, stress

More Related Videos

Cortisol Measurement in Koala Phascolarctos cinereus Fur
00:09

Cortisol Measurement in Koala Phascolarctos cinereus Fur

Published on: August 23, 2019

10.7K
An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
09:16

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap

Published on: January 16, 2014

14.4K

Related Experiment Videos

Last Updated: Jun 13, 2025

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
09:56

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

4.9K
Cortisol Measurement in Koala Phascolarctos cinereus Fur
00:09

Cortisol Measurement in Koala Phascolarctos cinereus Fur

Published on: August 23, 2019

10.7K
An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
09:16

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap

Published on: January 16, 2014

14.4K

Area of Science:

  • Endocrinology
  • Obesity research
  • Physiology

Background:

  • The adrenal gland is recognized as a key component of the 'Ominous Octet,' a group of endocrine factors implicated in obesity development.
  • Understanding the interplay between the adrenal gland and weight homeostasis is crucial for addressing the obesity epidemic.

Purpose of the Study:

  • To elucidate the multifaceted relationship between adrenal function and obesity.
  • To describe the bidirectional communication within the baro-adrenal axis.
  • To outline how adrenal function influences obesity and is, in turn, affected by it.

Main Methods:

  • Literature review and synthesis of existing research on the baro-adrenal axis.
  • Analysis of endocrine contributions to weight regulation.
  • Examination of physiological links between adrenal activity and body weight.

Main Results:

  • The adrenal gland significantly impacts weight homeostasis through various mechanisms.
  • Obesity, in turn, exerts considerable influence on adrenal gland function.
  • The baro-adrenal axis represents a dynamic and bidirectional regulatory system.

Conclusions:

  • Adrenal function is intrinsically linked to the development and maintenance of obesity.
  • The baro-adrenal axis is a critical pathway for understanding metabolic health and disease.
  • Targeting adrenal pathways may offer novel therapeutic strategies for obesity management.