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Updated: Jun 13, 2025

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

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Roles of leukemia inhibitory factor receptor in cancer

Wei Ma1, Haixu Yan2, Haoyuan Ma2

  • 1School of Stomatology, China Medical University, Shenyang, China.

International Journal of Cancer
|September 16, 2024
PubMed

Insights

Leukemia inhibitory factor receptor (LIFR) plays a complex role in cancer, influencing tumor growth and spread. Its varied effects highlight LIFR as a potential target for novel cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Leukemia inhibitory factor receptor (LIFR), complexed with gp130, is a receptor for leukemia inhibitory factor (LIF), a multifunctional cytokine.
  • LIF/LIFR signaling impacts tumor cell proliferation, apoptosis, migration, and invasion.
  • The role of LIFR in cancer is context-dependent, with varying effects across different tumor types and tissues.

Purpose of the Study:

  • To review the signaling pathways initiated by LIFR.
  • To summarize current literature on LIFR's role in human cancers.
  • To explore the therapeutic potential of LIFR in cancer treatment.

Main Methods:

  • Literature review of studies on LIFR signaling and cancer.
  • Analysis of LIFR's function in various tumor-related processes.
  • Evaluation of LIFR's expression and therapeutic implications.

Main Results:

  • LIFR activates signaling pathways like JAK/STAT3.
  • LIF/LIFR signaling can promote or inhibit tumor progression depending on the cellular context.
  • Aberrant LIFR expression is observed in numerous cancer cells.

Conclusions:

  • LIFR's dual role in tumorigenesis necessitates careful consideration for therapeutic strategies.
  • LIFR is a promising target for developing new cancer therapies.
  • Understanding LIFR signaling is crucial for cancer treatment and prognosis.
Keywords:
LIFLIFRcancer

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