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[Enzyme activity and ultrastructure of the intestinal epithelium in mice treated with rifampicin]
Bollettino Dell'Istituto Sieroterapico Milanese
|January 1, 1985
Abstract:
Some enzymatic activities and the ultrastructure of the intestinal epithelium of mouse were valued after a treatment with rifampicin, per os, in different doses (25 mg/Kg and 50 mg/Kg), for 90 days. Neither alteration of maltase, lactase, leucine aminopeptidase (LAP), nor modification of the morphology of jejunal mucous membrane enterocytes and of their mitochondria were noticed in treated animals, as to controls.
Insights
Rifampicin treatment did not alter intestinal enzymes like maltase or lactase. Mouse intestinal cell structure and mitochondria remained unaffected by rifampicin at tested doses.
Area of Science:
- Gastroenterology
- Pharmacology
- Cell Biology
Context:
- Investigating the effects of rifampicin on the gastrointestinal system.
- Evaluating potential drug-induced changes in intestinal function and structure.
Purpose:
- To assess the impact of oral rifampicin on specific enzymatic activities within the mouse intestinal epithelium.
- To examine ultrastructural changes in jejunal enterocytes and mitochondria following rifampicin administration.
Summary:
- Mice were treated with rifampicin (25 mg/Kg or 50 mg/Kg) for 90 days.
- No significant alterations were observed in maltase, lactase, or leucine aminopeptidase (LAP) activities compared to control groups.
- The morphology of jejunal enterocytes and their mitochondria remained unchanged in treated mice.
Impact:
- Provides crucial data on the gastrointestinal safety profile of rifampicin.
- Suggests rifampicin does not adversely affect key intestinal digestive enzymes or cellular ultrastructure at tested doses.
- Informs clinical practice regarding the use of rifampicin in patients with gastrointestinal considerations.