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Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis

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The pathological left-handedness syndrome.

P Satz, D L Orsini, E Saslow

Brain and Cognition

|January 1, 1985

Summary

Pathological left-handedness (PLH) is a proposed syndrome linked to early left-brain injury before age 6. This condition in left-handers involves developmental changes impacting handedness, speech, and spatial cognition.

Area of Science:

Neuroscience
Developmental Psychology
Clinical Neurology

Background:

Early brain injury can affect lateralization and cognitive development.
Left-handedness is sometimes associated with atypical brain organization.
Previous research has identified some correlates of brain injury in left-handers, but not as a distinct syndrome.

Purpose of the Study:

To propose and define a clinical syndrome of pathological left-handedness (PLH).
To identify the pattern of lateral developmental changes associated with early brain injury in left-handers.
To explore the implications of recognizing PLH for diagnosis, remediation, and understanding functional recovery.

Main Methods:

Clinical observation and analysis of developmental patterns in manifest left-handers.

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Correlation of specific neurological and cognitive features with early hemispheric lesions.

Review of existing literature on lateral development and brain injury.

Main Results:

Pathological left-handedness (PLH) is characterized by a pattern of correlative changes in lateral development.
These changes result from early (before age 6) left-sided or asymmetric brain lesions affecting speech zones.
Manifestations include shifts in manual dominance, extremity changes, speech transfer, and visuospatial reorganization.

Conclusions:

PLH represents a recognizable clinical syndrome in manifest left-handers with early brain injury.
Identifying PLH has significant implications for clinical diagnosis and intervention strategies.
Understanding PLH contributes to models of brain plasticity and recovery of function.