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Updated: Jun 13, 2025

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Tannic acid elicits differential gene regulation in prostate cancer apoptosis

Sinan Kandir1, Sevtap Karakurt2, Çiğdem Gökçek-Saraç3

  • 1Faculty of Veterinary Medicine, Department of Physiology, Çukurova University, 01920 Ceyhan Adana, Turkiye.

Acta Pharmaceutica (Zagreb, Croatia)
|September 16, 2024
PubMed

Insights

Tannic acid demonstrates anticancer properties by selectively inhibiting prostate cancer cell growth. It induces apoptosis by down-regulating pro-survival genes and up-regulating pro-apoptotic genes in prostate cancer cells.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Prostate cancer presents a significant global health challenge.
  • Innovative therapeutic strategies are crucial for effective treatment.
  • Tannic acid is explored for its potential anticancer effects.

Purpose of the Study:

  • To evaluate the anticancer properties of tannic acid.
  • To investigate its effects on apoptosis in prostate cancer cell lines.
  • To analyze gene expression changes induced by tannic acid.

Main Methods:

  • Cultured PC-3, LnCaP prostate cancer cells, and PNT1A control cells.
  • Treated cells with tannic acid and compared to untreated controls.
  • Assessed cell proliferation, cytotoxicity, and apoptosis.
  • Analyzed mRNA expression of 84 genes post-treatment.

Main Results:

  • Tannic acid down-regulated pro-survival genes (e.g., ATM, BCL2, CASP3, TRAF5).
  • Tannic acid up-regulated pro-apoptotic genes (e.g., BCL10, CASP1, FASLG, TP53).
  • These changes were observed in both PC-3 and LnCaP cell lines.

Conclusions:

  • Tannic acid induces apoptosis in prostate cancer cells via pro-apoptotic pathways.
  • Tannic acid selectively inhibits prostate cancer cell growth.
  • Tannic acid shows promise as a therapeutic agent for prostate cancer.
Keywords:
apoptosisgene regulationprostate cancerselective cytotoxicitytannic acid

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