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Emerging Nanotechnology Involved in Skin Cancer: Pathogenesis, Biomarkers, Ethosomal Formulation and Future

Milan Singh Kahlon1, Raj Kamal2, Amit Kumar1

  • 1Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, 142001, India.

Current Pharmaceutical Biotechnology
|September 16, 2024
PubMed

Insights

Ethosomes offer a promising solution for skin cancer treatment, enhancing drug delivery for improved efficacy and patient adherence. This novel approach addresses limitations of current therapies for melanoma and non-melanoma skin cancers.

Area of Science:

  • Dermatology and Nanotechnology
  • Cancer Research
  • Drug Delivery Systems

Background:

  • Skin cancer, including melanoma and non-melanoma types, is a prevalent malignancy with current treatments often being complex, lengthy, and having limited success rates.
  • Treatment challenges contribute to poor patient compliance and increased risk of cancer recurrence.
  • Ethosomes, lipid-based vesicles with high ethanol content, show potential for enhanced topical and transdermal drug delivery.

Purpose of the Study:

  • To review the potential of ethosomes as an advanced drug delivery system for skin cancer therapy.
  • To discuss the application of ethosomes in treating various skin cancers, including basal cell carcinoma, squamous cell carcinoma, and melanoma.
  • To highlight the advantages of ethosomes over conventional liposomes for dermatological applications.

Main Methods:

  • Literature review focusing on ethosome technology and its application in skin cancer treatment.
  • Analysis of ethosome composition, skin penetration enhancement mechanisms, and drug delivery efficiency.
  • Examination of studies investigating ethosomes for treating specific skin cancer types and relevant clinical trials.

Main Results:

  • Ethosomes demonstrate superior skin penetration and drug delivery efficiency compared to traditional liposomes due to their unique composition and high ethanol content.
  • Preclinical studies indicate potential efficacy of ethosomes in treating basal cell carcinoma, squamous cell carcinoma, and melanoma.
  • Ethosome-based formulations show promise in overcoming challenges associated with conventional skin cancer therapies.

Conclusions:

  • Ethosomes represent a promising nanocarrier system for developing effective topical and transdermal treatments for skin cancer.
  • The enhanced delivery capabilities of ethosomes could lead to improved therapeutic outcomes and patient adherence in skin cancer management.
  • Further research and clinical trials are warranted to fully establish the therapeutic role of ethosomes in combating skin malignancies.
Keywords:
Skin cancerbiomarkersclinical trialsethosomenanotechnology.signalling pathways

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