A Circadian Rhythm-related Signature to Predict Prognosis, Immune Infiltration, and Drug Response in Breast Cancer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.This study developed a six-gene signature based on circadian rhythm-related genes (CRRGs) to predict breast cancer (BC) prognosis. The signature accurately forecasts patient outcomes and may guide treatment strategies.
Area Of Science
- Oncology
- Genetics
- Chronobiology
Background
- Circadian rhythm-related genes (CRRGs) are implicated in cancer development.
- The prognostic value of CRRGs in breast cancer (BC) requires further investigation.
Purpose Of The Study
- To develop and validate a prognostic gene signature using CRRGs for breast cancer.
- To assess the signature's predictive accuracy and stability in BC prognosis.
Main Methods
- Utilized The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets for BC transcriptome and clinical data.
- Employed consensus unsupervised clustering and LASSO Cox regression to build a CRRGs-related risk model.
- Validated the model using Kaplan-Meier curves, ROC analysis, and nomograms; assessed correlations with immune infiltration, tumor mutation burden (TMB), and drug sensitivity.
Main Results
- A robust six-gene signature (SLC44A4, SLC16A6, TPRG1, FABP7, GLYATL2, FDCSP) was constructed and validated for BC prognosis.
- The low-risk group showed higher immune checkpoint gene expression and lower TMB.
- The signature demonstrated potential as a chemosensitivity predictor.
Conclusions
- A novel CRRGs-based risk signature effectively predicts breast cancer prognosis.
- This signature holds significant value for guiding clinical treatment decisions in BC patients.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...