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Published on: February 23, 2019
Changes in Energy Dynamics in Arsenic Exposure based Neurotoxicity: A Comprehensive Review
Anuj Choudhary1, Ruchi Pandey1, Debiprasad Padhy1
1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Hajipur, Vaishali, 844102, Bihar, India.
Background:
The by-product of naturally occurring rock, soil with different agricultural and industrial processes contaminated groundwater with a toxic metalloid- Arsenic (As3+), which results in different toxicities within the human body and in developing fetus.
Aim:
The present study emphasizes evaluating the presence of oxidative stress and excessive generation of reactive oxygen species (ROS) resulting in mitochondrial dysfunction and caspase activation followed by apoptosis due to arsenic-induced neurotoxicity along with epigenetic modifications at different molecular targets.
Methods:
Published articles available on PubMed and Scopus were studied and summarized.
Results:
The precise mechanism causing arsenic-induced neurotoxicity at a critical stage of brain development is still unknown, while increased oxidative stress led to mitochondrial dysfunctions which are known to play a prominent role in this. AMPK acts as a metabolic checkpoint and restores ATP levels through a different anabolic pathway in energy starvation. At the same time, arsenic-induced AMPK activation leads to autophagy and neuronal cell death.
Conclusion:
This review summarized the molecular mechanisms involved in arsenic-induced neurotoxicity, which can help to develop suitable future ameliorative and therapeutic strategies.
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