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Incidental testicular germ cell tumor in a transgender woman: A case report

R Evey Aslanian1,2, Cole Roblee1,3, David C Smith4

  • 1Section of Plastic Surgery, Department of Surgery, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI, USA.

Urology Case Reports
|September 16, 2024
PubMed

Keywords:
Asymptomatic malignancyGender-affirming orchiectomyGerm cell tumorTesticular cancer

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...