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Relationship between G protein level with left ventricular systolic function in children with acyanotic heart disease

Herlina Dimiati1, Mira Srikandi2, Te Haypheng3

  • 1Division of Cardiology, Department of Pediatrics, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.

Narra J
|September 16, 2024
PubMed

Insights

This study found no direct relationship between G protein levels and left ventricular systolic function in children with acyanotic congenital heart disease (CHD). Further research with larger sample sizes is recommended to confirm these findings in pediatric cardiology.

Area of Science:

  • Cardiology
  • Pediatric Medicine
  • Molecular Biology

Background:

  • Heart failure is a critical pediatric condition, often stemming from congenital heart disease (CHD).
  • G proteins are key regulators in cardiovascular system functions, including heart failure.
  • Understanding G protein involvement in pediatric heart conditions is crucial for effective treatment.

Purpose of the Study:

  • To investigate G protein levels in children diagnosed with acyanotic congenital heart disease.
  • To examine the correlation between G protein levels and left ventricular systolic function in this pediatric cohort.

Main Methods:

  • A cross-sectional study involving 38 children (0-18 years) with acyanotic CHD.
  • G protein levels were quantified using the ELISA method.
  • Left ventricular systolic function was assessed, and the Chi-squared test analyzed the relationship with G protein levels.

Main Results:

  • The mean G protein level was 36.25 ng/mL, and mean left ventricular systolic function was 73.1% in the study group.
  • No statistically significant relationship was identified between G protein levels and left ventricular systolic function in children with acyanotic CHD.

Conclusions:

  • The study did not find a direct association between G protein levels and left ventricular systolic function in pediatric acyanotic CHD.
  • Larger sample sizes and inclusion of additional variables are necessary for further investigation and validation of these results.

Keywords:
G proteinHeart failureacyanoticcongenital heart diseaseleft ventricular systolic function

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