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Relationship of left ventricular diastolic dysfunction with quality of life in heart failure patients with reduced

Sophia K Khaidirman1, Harris Hasan1, Cut A Andra1

  • 1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Narra J
|September 16, 2024
PubMed

Insights

The severity of left ventricular diastolic dysfunction significantly impacts the quality of life (QoL) in patients with heart failure with reduced ejection fraction (HFrEF). Addressing diastolic dysfunction is crucial for improving QoL in HFrEF patients.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Clinical Research

Background:

  • Heart failure with reduced ejection fraction (HFrEF) is often characterized by left ventricular (LV) diastolic dysfunction.
  • LV diastolic dysfunction significantly contributes to reduced quality of life (QoL) in HFrEF patients.

Purpose of the Study:

  • To investigate the association between the grade of LV diastolic dysfunction and QoL in HFrEF patients.
  • To identify potential targets for improving patient outcomes in HFrEF.

Main Methods:

  • Retrospective cohort study including 96 HFrEF patients (ejection fraction ≤40%).
  • Echocardiography assessed LV diastolic dysfunction severity (Grades I, II, III) using E/A ratio, E/e' ratio, TR Vmax, and LAVI.
  • Quality of life (QoL) evaluated using the Minnesota Living with Heart Failure Questionnaire (MLHFQ).

Main Results:

  • A significant relationship was found between the severity of LV diastolic dysfunction and QoL (p=0.040).
  • 80.2% of patients reported good QoL, while 19.8% reported poor QoL.
  • Higher grades of diastolic dysfunction were associated with poorer QoL.

Conclusions:

  • The degree of LV diastolic dysfunction is a significant determinant of QoL in HFrEF patients.
  • Comprehensive management strategies should address LV diastolic dysfunction to enhance QoL in HFrEF.
  • Further research into targeted therapies for diastolic dysfunction in HFrEF is warranted.

Keywords:
HFrEFLV diastolic dysfunctionMLHFQechocardiographyquality of life

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