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Protracted Course of Staphylococcus lugdunensis Septic Arthritis in Native Knee Joint

Sofia Howson1, Sara L Ma1, Jennifer Schmidt1

  • 1Department of Internal Medicine, Wayne State University School of Medicine, Detroit, USA.

Cureus
|September 16, 2024
PubMed

Insights

Staphylococcus lugdunensis can cause severe native joint infections, particularly in older adults with underlying health issues. Treatment noncompliance, influenced by social factors, can complicate recovery from these rare infections.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Clinical Case Study

Background:

  • Staphylococcus lugdunensis is a coagulase-negative Staphylococcus species known for its high invasiveness, comparable to Staphylococcus aureus.
  • While commonly linked to bacteremia and device-related infections, native joint infections are rare.
  • Risk factors include indwelling medical devices due to biofilm formation.

Observation:

  • A case of native right knee septic arthritis caused by Staphylococcus lugdunensis in a 72-year-old female with multiple comorbidities is presented.
  • The patient exhibited treatment noncompliance, influenced by social determinants of health, leading to a complex clinical course.
  • Treatment involved inpatient intravenous antibiotics followed by outpatient oral doxycycline.

Findings:

  • This case highlights the rarity of Staphylococcus lugdunensis native joint infections.
  • It underscores the significant impact of treatment noncompliance, exacerbated by social determinants of health, on the protracted course and sequelae of septic arthritis.
  • Comorbidities and socioeconomic factors appear to increase susceptibility to prolonged joint infections by this pathogen.

Implications:

  • This case expands the understanding of Staphylococcus lugdunensis pathogenicity in native joints.
  • It emphasizes the critical role of addressing social determinants of health and ensuring treatment compliance for managing complex infections.
  • Further research is warranted to explore the specific mechanisms and clinical outcomes of Staphylococcus lugdunensis native joint infections, especially in vulnerable populations.
Keywords:
infectious diseasesnative jointseptic arthritissocial determinantsstaphylococcus lugdunensis

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