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Application of warning biopsies in percutaneous nephrolithotomy
Jiajia Qiao1,2, Cong Tian1,2, Lizhe An1,2
1Urology Department, Peking University People's Hospital, Beijing, China.
Translational Andrology and Urology
|September 16, 2024
Summary
Percutaneous nephrolithotomy (PCNL) for kidney stones can reveal renal pelvic tumors. An early warning biopsy system based on patient factors and intraoperative findings aids in timely tumor detection and treatment.
Area of Science:
- Urology
- Nephrology
- Oncology
Background:
- Limited clinical guidance exists for percutaneous nephrolithotomy (PCNL) concerning renal calculi and co-existing renal pelvic tumors identified via intraoperative biopsy.
- This study investigates the relationship between kidney stones and renal pelvic tumors.
Purpose of the Study:
- To analyze the incidence and characteristics of renal pelvic tumors found during PCNL for kidney stones.
- To establish an early warning system for detecting tumors during PCNL procedures.
Main Methods:
- Retrospective analysis of medical records for patients undergoing PCNL for kidney stones with abnormal mucosal biopsy results.
- Data collected from January 2011 to November 2021 at Peking University People's Hospital.
Main Results:
- Of 2,801 patients undergoing PCNL, 69 had intraoperative mucosal biopsies.
- 8 biopsies (11.60%) were malignant (renal pelvic carcinoma), and 61 (88.40%) were benign.
- Risk factors for malignancy included advanced age, long stone history, hydronephrosis, UTIs, and complex stone types.
Conclusions:
- An early warning system integrating preoperative data and intraoperative observations is crucial for kidney stone patients.
- Performing early biopsies for suspected tumors during PCNL improves timely diagnosis and patient outcomes.
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