Construction and validation of a prediction model for inguinal lymph node metastasis of penile malignancy
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View abstract on PubMed
Summary
This summary is machine-generated.Identifying risk factors for inguinal lymph node metastasis (ILNM) in penile cancer is crucial for survival. A predictive model using clinicopathological features and tumor markers demonstrated good accuracy in assessing ILNM risk.
Area Of Science
- Oncology
- Urology
Background
- Penile squamous cell carcinoma is a rare but serious malignancy.
- Inguinal lymph node metastasis (ILNM) significantly impacts survival in penile cancer patients.
- Accurate prediction of ILNM is essential for effective treatment strategies.
Purpose Of The Study
- To identify key risk factors associated with ILNM in penile cancer.
- To develop a precise prediction model for ILNM in penile malignancies.
- To improve patient survival rates through early and accurate metastasis detection.
Main Methods
- Retrospective analysis of 112 male penile cancer patients.
- Utilized Fisher's exact test, t-test, and Wilcoxon rank sum test for demographic and clinical feature comparison.
- Employed Least Absolute Shrinkage and Selection Operator (LASSO) regression to determine ILNM risk factors and constructed a nomogram-based prediction model.
Main Results
- Age, smoking history, and IL-2 levels were found to be protective against ILNM.
- Lymph node diameter, T-stage, fibrinogen, IL-4 levels, and neutrophil-to-lymphocyte ratio were identified as significant risk factors for ILNM.
- The developed prediction model showed a good predictive ability with an Area Under the Curve (AUC) of 0.81, and the nomogram achieved an AUC of 0.75.
Conclusions
- Clinicopathological features, biochemical tests, and tumor markers can effectively predict ILNM in penile cancer.
- The developed prediction model and nomogram offer a valuable tool for assessing ILNM risk.
- Accurate ILNM diagnosis aids in personalized treatment planning and improved patient outcomes.
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