Related Experiment Video
Updated: Jun 13, 2025
09:32
Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation
Published on: September 19, 2018
15.3K
Endoplasmic reticulum stress in abdominal aortic aneurysm.
Zhaohai Su1,2, Weiling Lu2, Jun Cao2
1Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu 225001, PR China.
International Journal of Cardiology. Heart & Vasculature
|September 16, 2024
Summary
Abdominal aortic aneurysms involve aorta dilation and cellular stress. Understanding endoplasmic reticulum stress in abdominal aortic aneurysms is crucial for developing new treatments.
Area of Science:
- Vascular Biology
- Cellular Stress Response
Background:
- Abdominal aortic aneurysms (AAAs) involve aorta dilation, inflammation, extracellular matrix degradation, and vascular smooth muscle cell (VSMC) dysfunction.
- Endoplasmic reticulum (ER) stress is implicated in inflammation, oxidative stress, and VSMC apoptosis, key factors in AAA pathogenesis.
Purpose of the Study:
- To investigate the largely unknown specific biological functions of ER stress in the development of AAAs.
- To explore the physiological and pathological roles of ER stress in AAA development.
Main Methods:
- This study focuses on the role of ER stress in AAA development, building upon existing evidence of its occurrence.
- Further investigation into the mechanisms linking ER stress to AAA pathogenesis is warranted.
Main Results:
- Studies indicate ER stress occurs during AAA development.
- The precise functions of ER stress in AAA pathogenesis remain to be fully elucidated.
Conclusions:
- Targeting ER stress presents a promising therapeutic strategy for treating AAAs.
- Further research is essential to fully understand and leverage the role of ER stress in AAA development and treatment.
Related Concept Videos
01:37The Unfolded Protein Response
4.5K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
4.5K
01:17Role of ER in the Secretory Pathway
5.3K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
5.3K
01:31Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
01:21Smooth Endoplasmic Reticulum
5.7K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
5.7K