Effects of eight amino acids on the exocrine and endocrine pancreatic function

Eight amino acids were intravenously administered in a dose of 2 mmoles/kg/hr to dogs with chronic pancreatic fistula, and the effect of each amino acid on endocrine and exocrine pancreatic secretions was investigated. Asparagine, arginine, isoleucine and phenylalanine administered under the stimulation of secretin-pancreozymin significantly inhibited the secretion of pancreatic juice by 23%, 15%, 13% and 13%, and the output of amylase by 53%, 37%, 27% and 18%, respectively. Threonine, glycine or methionine brought about no significant changes in pancreatic secretion, but valine significantly increased pancreatic juice secretion by 13% and amylase output by 15%. Any of the eight amino acids caused no noticeable change in the concentration of bicarbonate.