A modified sampling method for the precise detection of prostate cancer tissues using a three-dimensional stereotaxic...

Area of Science:

• Urological Oncology
• Medical Imaging
• Pathological Sampling Techniques

Background:

• Accurate acquisition of prostate cancer pathological tissue is crucial for research but historically challenging.
• Three-dimensional (3D) modeling offers potential solutions to limitations in traditional tissue sampling.
• This study compares 3D stereotaxic sampling with cognitive sampling to identify factors influencing accuracy.

Purpose of the Study:

• To compare the efficacy of 3D stereotaxic sampling versus traditional cognitive sampling for prostate cancer tissue acquisition.
• To identify and analyze factors influencing the positive sampling rate in both methods.

Main Methods:

• A cohort study analyzed 111 men undergoing radical prostatectomy for prostate cancer.
• Compared positive sampling rates and influencing factors (age, BMI, PSA, ISUP grade, tumor volume, etc.) between cognitive and 3D stereotaxic methods.
• Statistical analysis was performed to determine significant differences and identify key factors.

Main Results:

• The 3D stereotaxic sampling method achieved a significantly higher positive rate (61.11%) compared to cognitive sampling (29.82%) (P=0.001).
• Factors like tumor volume, positive biopsy cores, PI-RADS score, and clinical T stage influenced cognitive sampling rates.
• These influencing factors were eliminated in the 3D stereotaxic sampling group, showing no statistical significance.

Conclusions:

• The 3D stereotaxic sampling method enables accurate and rapid acquisition of prostate cancer tissue.
• This technique effectively eliminates factors that previously compromised the positive sampling rate.
• 3D stereotaxic sampling represents a significant advancement for prostate cancer research and pathological analysis.