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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Primary Site Surgical Resection In Cm1 Oral Cavity Squamous Cell Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Primary Site Surgical Resection In Cm1 Oral Cavity Squamous Cell Carcinoma.

Related Experiment Video

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

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Primary site surgical resection in cM1 oral cavity squamous cell carcinoma.

Aman M Patel1, Afash Haleem1, Lucy Revercomb1

  • 1Department of Otolaryngology-Head and Neck Surgery Rutgers New Jersey Medical School Newark New Jersey USA.

Laryngoscope Investigative Otolaryngology
|September 16, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Surgical resection plus chemoradiotherapy improved overall survival for patients with distant metastatic oral cavity squamous cell carcinoma (cM1 OCSCC). This approach may benefit select patients despite challenges like positive surgical margins.

Keywords:
National Cancer Databasemetastasisoral cavitysurgical resection

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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Oral cavity squamous cell carcinoma (OCSCC) with distant metastasis (cM1) presents a significant treatment challenge.
  • Optimal management strategies for cM1 OCSCC, particularly regarding the role of primary site surgical resection, require further investigation.

Purpose of the Study:

  • To evaluate the impact of primary site surgical resection on overall survival (OS) in patients with clinically distantly metastatic (cM1) oral cavity squamous cell carcinoma (OCSCC).
  • To compare survival outcomes across different treatment modalities, including chemotherapy, chemoradiotherapy, and surgical interventions with adjuvant therapies.

Main Methods:

  • Analysis of the National Cancer Database (2006-2018) for patients with cM1 OCSCC who received chemotherapy.
  • Utilized binary logistic regression, Kaplan-Meier analysis, and multivariable Cox proportional hazards regression models to assess treatment effects and survival.
survival
  • Compared outcomes for chemotherapy alone, chemoradiotherapy, surgical resection + adjuvant chemotherapy, and surgical resection + adjuvant chemoradiotherapy.

    • Main Results:

    • Surgical resection + adjuvant chemoradiotherapy was associated with significantly higher 5-year OS (23.8%) compared to chemotherapy alone (9.4%), chemoradiotherapy (15.2%), and surgical resection + adjuvant chemotherapy (8.3%).
    • Patients undergoing surgical resection received radiotherapy more often but multi-agent chemotherapy less frequently than those without surgery.
    • Positive surgical margins were observed in 36.2% of patients undergoing surgical resection; however, this approach, along with chemoradiotherapy and immunotherapy, was linked to improved OS.

    Conclusions:

    • Primary site surgical resection, particularly when combined with adjuvant chemoradiotherapy, demonstrates a survival benefit for select patients with cM1 OCSCC.
    • Despite a high rate of positive margins, definitive local therapy including surgical resection may be a valuable component of treatment for advanced OCSCC.
    • Further research into patient selection for surgical intervention in cM1 OCSCC is warranted to optimize outcomes.