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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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The association between klotho and kidney and cardiovascular outcomes: a comprehensive systematic review and

Mehmet Kanbay1, Crischentian Brinza2,3, Lasin Ozbek4

  • 1Department of Medicine, Division of Nephrology, Koç University School of Medicine, Istanbul, Turkey.

Clinical Kidney Journal
|September 16, 2024
PubMed

Insights

Lower klotho levels in chronic kidney disease (CKD) patients predict higher mortality and adverse renal events. This finding highlights klotho as a key prognostic marker for kidney disease progression and patient outcomes.

Area of Science:

  • Nephrology
  • Biomarkers
  • Chronic Disease Management

Background:

  • Chronic kidney disease (CKD) and end-stage renal disease (ESKD) present significant global health challenges.
  • These conditions are linked to progressive kidney dysfunction, cardiovascular disease, and increased mortality.
  • Investigating prognostic markers is crucial for managing CKD and ESKD patients.

Purpose of the Study:

  • To explore the association between plasma klotho levels and prognostic outcomes in CKD and ESKD patients.
  • To evaluate klotho's role in predicting all-cause mortality, cardiovascular events, and adverse renal events.
  • To assess the relationship between klotho levels and the need for renal replacement therapies.

Main Methods:

  • A systematic literature review was conducted using major electronic databases (PubMed, MEDLINE, Web of Science, etc.).
  • The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
  • Fourteen studies were included in the analysis.

Main Results:

  • Lower klotho levels were significantly associated with increased all-cause mortality (OR 1.81) and cardiovascular mortality (OR 2.11).
  • Patients with low klotho showed a higher risk of adverse renal events (OR 2.36) and progression to ESKD or kidney replacement therapy (OR 2.30).
  • While composite cardiovascular events did not show a significant difference, heterogeneity was high.

Conclusions:

  • Reduced serum klotho levels are a significant predictor of adverse outcomes in CKD patients.
  • Low klotho is associated with increased risks of mortality and progression to end-stage kidney disease.
  • Klotho may serve as a valuable prognostic biomarker in the management of kidney disease.
Abstract

Keywords:
all-cause mortalitycardiovascular mortalitychronic kidney diseaseend-stage kidney diseaseklotho

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