Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

746
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
746
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

3.4K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.4K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

110
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
110

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-region proteomic mapping identifies FTL1 and SERPINA3K as protective factors in cardiac aging.

Cell death & disease·2026
Same author

Multi-omics landscape and machine learning predictors of acute and chronic coronary syndrome diagnosis in young patients.

Journal of advanced research·2026
Same author

Stabilizing the Sealing Performance of EPDM by the Incorporation of a ZIF-8 Network.

Polymers·2026
Same author

An efficient tissue-culture-free soybean genetic transformation technology using the extremely simple cut-dip-budding strategy.

Innovation (Cambridge (Mass.))·2026
Same author

Degradation-Aware Dynamic Kernel Generation Network for Hyperspectral Super-Resolution.

Sensors (Basel, Switzerland)·2026
Same author

Cytoskeletal remodeling via CAMSAP3 downregulation drives resistance to osimertinib in NSCLC cells.

Cell death & disease·2025

Related Experiment Video

Updated: Jun 13, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.3K

Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway.

Yongshun Wang1,2, Jie Yuan1,2, Huadong Liu1,2

  • 1Department of Cardiology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China.

Genes & Diseases
|September 16, 2024
PubMed
Summary

High-intensity interval training (HIIT) improves heart failure (HF) by increasing meteorin-like protein (Metrnl). This protein enhances cardiac function through improved glucose metabolism and mitochondrial activity via the AMPK-HDAC4 pathway.

Keywords:
AMPKGLUT4HDAC4Heart failureHigh intensity interval trainingMeteorin-like protein

More Related Videos

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
09:19

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

9.8K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

796

Related Experiment Videos

Last Updated: Jun 13, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

7.3K
Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
09:19

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

9.8K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

796

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Molecular Biology

Background:

  • High-intensity interval training (HIIT) shows greater efficacy than moderate-intensity continuous aerobic training (MICT) in alleviating heart failure (HF) symptoms.
  • Elevated meteorin-like protein (Metrnl) levels are observed post-HIIT compared to MICT.

Purpose of the Study:

  • To investigate the role of Metrnl in post-HF cardiac functional improvements.
  • To elucidate the signaling pathways involved in Metrnl-mediated cardiac benefits.

Main Methods:

  • 50 HF patients each underwent MICT and HIIT, followed by cardiac function and serum Metrnl measurements.
  • Mice with HF underwent HIIT, with Metrnl measured in blood and skeletal muscle. Genetic manipulation (shRNA) was used to assess Metrnl's function in vivo.
  • Signaling pathways were identified using mass spectrometry and confirmed with biochemical analyses. Cardiomyocyte glucose metabolism and mitochondrial function were evaluated.

Main Results:

  • Both HF patients and mice exhibited increased circulating Metrnl levels after HIIT.
  • Metrnl activated AMPK in cardiomyocytes, leading to HDAC4 phosphorylation and inactivation.
  • HDAC4 inactivation enhanced glucose transporter type 4 (GLUT4) expression and mitochondrial complex expression, improving aerobic glucose respiration and mitochondrial function.

Conclusions:

  • HIIT enhances skeletal muscle Metrnl production, which acts on the heart to improve function.
  • The AMPK-HDAC4 signaling pathway mediates Metrnl's beneficial effects on cardiac glucose metabolism and mitochondrial health in HF.
  • Metrnl plays a crucial role in mediating the cardioprotective effects of HIIT in heart failure.