Myelofibrosis, autoimmune haemolytic anaemia and Tn-polyagglutinability

A patient with myelofibrosis was studied for about four years. During this period he developed autoimmune haemolytic anaemia, a rare complication of myelofibrosis. Furthermore, about two years after the investigation started, his red blood cells, previously normal, became Tn-polyagglutinable, a change known to be due to somatic mutation in haemopoietic stem cells.