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Related Experiment Video

Updated: Jun 13, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Technologies for Decoding Cancer Metabolism with Spatial Resolution.

Walter W Chen1, Michael E Pacold2, David M Sabatini3

  • 1Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Cold Spring Harbor Perspectives in Medicine
|September 16, 2024
PubMed
Summary
This summary is machine-generated.

Cancer cells adapt metabolism for survival and drug resistance. Emerging metabolomic technologies like spatial, single-cell, and organellar profiling offer new insights into cancer metabolism and treatment strategies.

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Area of Science:

  • Oncology
  • Metabolomics
  • Biochemistry

Background:

  • Cancer cells exhibit metabolic adaptability for growth and survival, even in nutrient-poor tumor microenvironments.
  • Metabolic reprogramming enables cancer cells to evade therapies targeting essential metabolic pathways, such as nucleotide synthesis.

Purpose of the Study:

  • To review emerging metabolomic technologies for cancer research.
  • To highlight the potential of advanced metabolomic approaches in understanding cancer metabolism.

Main Methods:

  • Discusses metabolite profiling (metabolomics) using mass spectrometry.
  • Introduces three emerging technologies: spatial metabolomics, single-cell metabolomics, and organellar metabolomics.
  • Mentions integration with single-cell transcriptomics and proteomics.

Main Results:

  • Metabolomics enables detection and quantification of metabolites in cancer cells and their surroundings.
  • Technological advancements are driving innovation in metabolomic analysis.
  • Emerging techniques allow for more precise analysis of metabolic heterogeneity.

Conclusions:

  • Advanced metabolomic technologies are crucial for uncovering new cancer biology.
  • These methods, combined with existing profiling techniques, will drive future discoveries in cancer research.
  • Understanding cancer metabolism is key to developing novel therapeutic strategies.