Multifunctional EGCG@ZIF-8 Nanoplatform with Photodynamic Therapy/Chemodynamic Therapy Antibacterial Properties...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Damaged skin is vulnerable to bacterial infections, delaying healing.
• Epigallocatechin-3-gallate (EGCG) has wound healing and anti-inflammatory benefits but is unstable.
• Zeolitic imidazolate framework-8 (ZIF-8) can stabilize EGCG.

Purpose of the Study:

• To create a self-oxygenating and hydrogen peroxide-supplying ZIF-8 nanoplatform for enhanced EGCG delivery.
• To combine photodynamic therapy (PDT) and chemodynamic therapy (CDT) for improved antibacterial efficacy.
• To accelerate infected wound healing using a multifunctional nanoplatform.

Main Methods:

• Synthesized EGCG-ICG@ZIF-8 nanoparticles, coated with BSA, and modified with MnO2 and CaO2 (EIZBMC).
• Investigated synergistic antibacterial effects of PDT and CDT via reactive oxygen species (ROS) generation in vitro.
• Evaluated EIZBMC efficacy in a murine wound infection model.

Main Results:

• EIZBMC demonstrated synergistic antibacterial activity through combined PDT and CDT, generating ROS.
• The nanoplatform effectively inhibited bacterial growth in vitro.
• In vivo studies showed EIZBMC accelerated wound healing, reduced inflammation, and promoted collagen regeneration.

Conclusions:

• The EIZBMC nanoplatform enhances EGCG's therapeutic potential through synergistic PDT and CDT.
• This approach offers a promising strategy for treating infected wounds by maximizing anti-inflammatory and antibacterial effects.
• The multifunctional nanoplatform effectively promotes infected wound healing.