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Formation of Complex Ions

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...

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Developing a novel calcium silver zeolite for caries management.

Laura Jiaxuan Li¹, Christie Ying-Kei Lung¹, Kelsey Xingyun Ge¹

¹Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Hong Kong, S.A.R., China.

BMC Oral Health

|September 16, 2024

Summary

A novel calcium silver zeolite (Ca-Ag-Zeo) shows improved biocompatibility over silver zeolite X (Ag-Zeo). This new material sustainably releases calcium and silver ions, effectively inhibiting cariogenic microorganisms like Streptococcus mutans and Candida albicans.

Keywords:

Antimicrobial Calcium Dental Caries Prevention Silver Zeolite

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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Area of Science:

Materials Science
Biomaterials Engineering
Nanotechnology

Background:

Dental caries is a prevalent global health issue.
Microbial biofilms on teeth contribute significantly to caries development.
Novel antimicrobial agents are needed to combat cariogenic bacteria.

Purpose of the Study:

To synthesize and characterize a novel calcium silver zeolite (Ca-Ag-Zeo).
To evaluate the biocompatibility, physiochemical properties, and antimicrobial efficacy of Ca-Ag-Zeo.
To compare Ca-Ag-Zeo with silver zeolite X (Ag-Zeo) and plain Zeolite X (Zeo).

Main Methods:

Ca-Ag-Zeo synthesized via ion-exchange with Zeolite X, calcium chloride, and silver nitrate.
Characterization using XRD, SEM, TEM, and EDS.
Biocompatibility assessed using cell counting kit-8 assay on human gingival fibroblasts.
Ion release quantified by ICP-Emission Spectrometry.
Antimicrobial activity determined by minimum bactericidal/fungicidal concentration assays against key oral microorganisms.

Main Results:

Ca-Ag-Zeo synthesized with a hexagonal cage structure.
Ca-Ag-Zeo demonstrated better biocompatibility than Ag-Zeo in human gingival fibroblasts.
Sustained release of calcium and silver ions observed from Ca-Ag-Zeo over 12 weeks.
Ca-Ag-Zeo exhibited significant antimicrobial activity against Streptococcus mutans, Lactobacillus acidophilus, Lactobacillus casei, and Candida albicans.

Conclusions:

A novel Ca-Ag-Zeo material was successfully developed.
Ca-Ag-Zeo offers superior biocompatibility compared to Ag-Zeo.
The material exhibits sustained ion release and potent inhibitory effects on cariogenic microorganisms, indicating potential dental applications.