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The roles of OGT and its mechanisms in cancer

Xin Liu1, Jing Wang1, Yaoxian Xiang1

  • 1Department of Oncology, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, 101149, China.

Cell & Bioscience
|September 16, 2024
PubMed

Insights

O-linked N-acetylglucosaminylation (O-GlcNAcylation), regulated by O-linked N-acetylglucosamine transferase (OGT), is crucial in cancer. Targeting OGT offers a promising strategy for treating various human malignancies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a prevalent post-translational modification (PTM) impacting protein function.
  • O-linked N-acetylglucosamine transferase (OGT) is the key enzyme catalyzing O-GlcNAcylation.
  • Aberrant O-GlcNAcylation and OGT are implicated in numerous cancers.

Purpose of the Study:

  • To review the biochemical functions of OGT.
  • To summarize the role and mechanisms of OGT in tumor progression.
  • To highlight OGT as a therapeutic target in oncology.

Main Methods:

  • Literature review of OGT and O-GlcNAcylation in cancer.
  • Analysis of biochemical pathways involving OGT.
  • Synthesis of current research on OGT's role in tumor biology.

Main Results:

  • OGT modulates protein stability, activity, and interactions.
  • OGT overexpression correlates with tumor growth, invasion, metabolism, and drug resistance.
  • O-GlcNAcylation influences cancer immune evasion.

Conclusions:

  • OGT plays a multifaceted role in cancer development and progression.
  • Targeting OGT is a potential therapeutic strategy for human cancers.
  • Further research into OGT inhibition may lead to novel anti-cancer treatments.
Keywords:
Cancer-promoting factorDrug resistanceImmune evasionO-GlcNACylationOGT

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