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Amyloidosis Found in the Breast: A Case Report
Dinh N Nguyen1, Abid Qureshi1, Michael A Salvian1
1Department of Surgery, Brooklyn Hospital Center, Brooklyn, NY, USA.
The American Journal of Case Reports
|September 17, 2024
Summary
This study details a rare case of breast amyloidosis, a condition involving protein deposits. It highlights the importance of recognizing this entity and its potential associations with breast cancer.
Area of Science:
- Pathology
- Oncology
- Radiology
Background:
- Breast amyloidosis is a rare condition characterized by extracellular deposition of beta-pleated protein.
- It can manifest locally or systemically, often presenting unilaterally, and has been linked to breast cancer.
- Few major case series exist, underscoring its rarity.
Observation:
- A 60-year-old woman presented with a breast lesion later diagnosed via biopsy as nodular amyloid deposition with calcifications.
- Microscopic examination revealed extracellular amyloid deposits in breast tissue and blood vessels, confirmed by Congo red staining and polarized light microscopy.
- Surgical excision confirmed the diagnosis of breast amyloidosis.
Findings:
- Breast amyloidosis exhibits calcium affinity and can elicit a foreign body giant cell reaction.
- Amyloid deposits can distribute periductally, perivascularly, or intralobarly within the breast.
- Associated risk factors include autoimmune diseases, breast cancers, and B-cell lymphomas.
Implications:
- Treatment of breast amyloidosis depends on its primary or secondary etiology.
- Further research is needed to identify potential genetic markers predisposing individuals to breast amyloidosis.
- Recognizing breast amyloidosis is crucial for appropriate patient management and understanding its oncologic associations.
