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Updated: Jun 13, 2025

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Recognition and Management of Delirium in the Neonatal Intensive Care Unit: Case Series From a Single-Center Level 4

Stacey Dornette1, Stephen Deptola2, Brianna Hemmann2

  • 1Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital, Cincinnati, OH, USA.

Journal of Child Neurology
|September 17, 2024
PubMed

Insights

Pediatric delirium is often missed due to subtle symptoms and lack of awareness. This study explored using quetiapine to treat delirium in medically complex neonates, offering a potential treatment approach.

Area of Science:

  • Neonatal medicine
  • Pediatric neurology
  • Pharmacology

Background:

  • Delirium in neonates and children is frequently underdiagnosed.
  • Limited data exist for pharmacologic treatment of pediatric delirium.
  • Nondistinctive symptoms and lack of clinical experience contribute to underrecognition.

Purpose of the Study:

  • To present a case series on quetiapine use for neonatal delirium.
  • To propose a monitoring and treatment approach for neonatal and infant delirium.

Main Methods:

  • Retrospective single-center case series.
  • Involved 9 medically complex neonates treated with quetiapine.
  • Literature review, expert opinion, and institutional experience informed the proposed approach.

Main Results:

  • Experience using quetiapine in 9 medically complex neonates with delirium is presented.
  • Data guiding pharmacologic treatment in this population are scarce.

Conclusions:

  • Quetiapine was used to treat delirium in medically complex neonates.
  • An approach for monitoring and treating delirium in neonates and infants is proposed based on current evidence and experience.

Keywords:
neonateoutcometreatment

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