A bio-functional cryogel with antioxidant activity for potential application in bone tissue repairing

Antioxidant and free radical resistance has been a key concern of tissue engineering. In this study, Hydroxyapatite (HAp) with osteogenic activity and Oligomeric Proantho Cyanidins (OPC) with antioxidant activity were chemically grafted to prepare gelatin-based biofunctional aerogel (GHPOS). SEM results confirmed that these aerogels exhibited obvious macroporous structure and could provide a suitable microenvironment for bone cell growth. The addition of HAP-PEI-OPC made it have good antioxidant activity, and the cell results proved that the aerogel prepared in this study had good cytocompatibility and did not produce cytotoxicity. The addition of nanoparticles played an important role in the activity of 3T3-E1. The results showed that these bioactive aerogel scaffolds have potential applications in bone tissue engineering.