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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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The Thyroid Gland01:23

The Thyroid Gland

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Analysis Of Risk Factors For Papillary Thyroid Carcinoma And The Association With Thyroid Function Indicators.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Analysis Of Risk Factors For Papillary Thyroid Carcinoma And The Association With Thyroid Function Indicators.

Related Experiment Video

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
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Analysis of risk factors for papillary thyroid carcinoma and the association with thyroid function indicators.

Jianning Liu1,2, Zhuoying Feng3, Ru Gao1,2

  • 1Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang, China.

Frontiers in Endocrinology
|September 17, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Urinary iodine concentration (UIC) predicts papillary thyroid carcinoma (PTC). Thyroid stimulating hormone (TSH) levels show diagnostic value for PTC, correlating with BMI and UIC.

Keywords:
BMIPTCROC curveTSH

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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
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Area of Science:

  • Endocrinology
  • Oncology
  • Epidemiology

Background:

  • Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer.
  • Understanding risk factors and diagnostic markers for PTC is crucial for early detection and management.

Purpose of the Study:

  • To investigate the relationship between papillary thyroid carcinoma (PTC) and factors including body mass index (BMI), thyroid stimulating hormone (TSH) levels, and urinary iodine concentration (UIC).
  • To evaluate the diagnostic value of TSH levels for PTC.

Main Methods:

  • Comparative analysis between PTC patients and controls.
  • Binary logistic regression and Lasso regression for risk factor identification.
  • Spearman's rank correlation for assessing relationships.
iodine
  • Receiver Operating Characteristic (ROC) curve analysis for diagnostic value assessment of TSH.

    • Main Results:

    • PTC patients had significantly higher BMI and TSH levels compared to controls.
    • Urinary iodine concentration (UIC) was identified as an independent predictor of PTC.
    • TSH levels demonstrated diagnostic utility for PTC with an optimal threshold of 2.4 mIU/L (AUC=67.3%).
    • TSH levels showed positive correlations with BMI and UIC.

    Conclusions:

    • Urinary iodine concentration (UIC) may serve as an independent predictor for papillary thyroid carcinoma (PTC).
    • Thyroid stimulating hormone (TSH) levels possess diagnostic value in identifying PTC.