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Updated: Jun 13, 2025

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The causal association between gut microbiota and postpartum depression: a two-sample Mendelian randomization study.

Wenjun Jin1, Bo Li2, Lijun Wang2

  • 1Medical Department, Sias University, Zhengzhou, Henan, China.

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|September 17, 2024
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Summary

This study used Mendelian randomization to investigate the gut microbiome

Keywords:
Mendelian randomizationgut microbiotainstrumental variables (IVs)postpartum depressionsingle nucleotide polymorphisms (SNPs)

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Area of Science:

  • Genetics
  • Microbiology
  • Psychiatry

Background:

  • Emerging evidence suggests a link between gut microbiota and postpartum depression (PPD).
  • The exact causal relationship remains unclear.
  • This study investigates the causal link using a robust genetic approach.

Purpose of the Study:

  • To determine the causal relationship between gut microbiota composition and the risk of postpartum depression (PPD).
  • To identify specific bacterial taxa associated with PPD risk.
  • To explore potential therapeutic targets for PPD based on gut microbiome modulation.

Main Methods:

  • Two-sample Mendelian randomization (MR) analysis was employed.
  • Genome-wide association study (GWAS) data for gut microbiota were sourced from MiBioGen and the Dutch Microbiome Project.
  • GWAS data for PPD were obtained from the FinnGen biobank (57,604 cases, 596,601 controls).
  • Inverse variance weighted (IVW) method was the primary analytical tool, supplemented by pleiotropy and heterogeneity tests.

Main Results:

  • Twelve bacterial taxa were found to be associated with PPD risk.
  • Specific taxa like Veillonellaceae and Bifidobacterium adolescentis showed an inverse association with PPD risk.
  • Other taxa, including Alphaproteobacteria and Alistipes onderdonkii, were positively correlated with PPD risk.

Conclusions:

  • A causal relationship between specific gut microbial communities and PPD was identified.
  • Findings suggest potential for microbial-based interventions in PPD treatment.
  • This research provides a foundation for using gut microbiota as biotherapeutics for neurological disorders.