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Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
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Extragastrointestinal stromal tumors with diffuse membranous distribution with bleeding: A case report.
Jian-Duo Xu1, Zheng Wang2, Qian Zhou3
1Department of Gastrointestinal Surgery, Shijiazhuang People's Hospital, Shijiazhuang 050000, Hebei Province, China.
World Journal of Clinical Cases
|September 17, 2024
Summary
This case report details a rare extragastrointestinal stromal tumor (EGIST) found diffusely in the abdominal cavity. Treatment with imatinib showed significant improvement in symptoms and tumor reduction.
Area of Science:
- Gastrointestinal Oncology
- Surgical Pathology
- Medical Genetics
Background:
- Extragastrointestinal stromal tumors (EGIST) share pathological similarities with gastrointestinal stromal tumors.
- EGISTs are rare neoplasms that can arise anywhere along the gastrointestinal tract or adjacent structures.
Observation:
- A 71-year-old male presented with abdominal pain and was diagnosed with diffuse EGIST in the abdominal cavity.
- Imaging revealed multiple nodules, enlarged lymph nodes, and pulmonary nodules, with elevated CA-125.
- Intraoperative findings included diffuse tuberous tumors and hematocelia, confirmed as EGIST post-pathology.
Findings:
- Gene testing identified variations in breast cancer susceptibility gene 1 interacting protein C-terminal helicase 1 and KIT.
- The patient received imatinib therapy, leading to symptom resolution.
- Post-treatment imaging demonstrated significant alleviation of tumor burden.
Implications:
- This case highlights the potential for diffuse EGIST in membranous tissues and its response to targeted therapy.
- Understanding genetic variations is crucial for effective treatment strategies in EGIST.
- Imatinib demonstrates therapeutic efficacy in managing complex EGIST presentations.
Keywords:
Diffuse tumor in abdominal cavityDiffusely membranous metastasisExtragastrointestinal stromal tumorsGastrointestinal stromal tumorsMalignant extragastrointestinal stromal tumorsMore Related Videos
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