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Related Experiment Video

Updated: Jun 13, 2025

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

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Published on: March 15, 2024

Acute Phase Peyronie's Disease: Where Do We Stand?

Konstantinos Douroumis¹, Konstantinos Kotrotsios¹, Panagiotis Katsikatsos¹

¹Department of Urology, National and Kapodistrian University of Athens, Athens, GRC.

|September 17, 2024

Summary

Peyronie's disease (PD) management focuses on conservative treatments during the acute phase, avoiding surgery. Current optimal strategies combine therapies like PDE5Is, ESWT, PTT, and intralesional injections.

Keywords:

acute phase andrology male sexual health penile curvature peyronie disease

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Area of Science:

Urology
Andrology
Regenerative Medicine

Background:

Peyronie's disease (PD) involves penile fibrosis and curvature.
Micro-traumas and inflammation are key pathogenetic factors.
PD presents in acute and chronic phases, with pain characteristic of the acute stage.

Purpose of the Study:

To review conservative treatment options for acute phase Peyronie's disease.
To identify current optimal treatment strategies for acute PD.
To highlight the need for further research in acute PD management.

Main Methods:

Review of conservative treatment modalities for acute Peyronie's disease.
Discussion of oral, topical, intralesional therapies, ESWT, and PTT.
Synthesis of current evidence for combined treatment approaches.

Main Results:

Conservative treatments are recommended for acute phase PD to avoid surgical risks.
A combined strategy including PDE5Is, ESWT, PTT, and intralesional therapies is currently considered optimal.
Pain management is a primary goal during the acute phase.

Conclusions:

Optimal management of acute Peyronie's disease involves a multimodal conservative approach.
Further large-scale randomized controlled trials are essential to confirm the efficacy of various treatment options.
Avoiding surgery during the acute phase is crucial for better long-term outcomes.