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Anaplastic Plasma Cell Myeloma With Peritoneal Involvement.
Verónica Roldán Galiacho1, Laura Zaldumbide Dueñas2, Ana Iglesias Perez1
1Department of Hematology, Cruces University Hospital, Barakaldo (Bizkaia), Spain.
Diagnostic Cytopathology
|September 17, 2024
Summary
Anaplastic myeloma, a rare B-cell cancer, can present with malignant ascites at diagnosis. This case highlights extramedullary involvement in anaplastic multiple myeloma at initial presentation.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Multiple myeloma (MM) is a B-cell neoplasm comprising 15% of hematological malignancies.
- Typical MM presentation involves hypercalcemia, renal failure, anemia, and bone lesions (CRAB criteria).
- Extramedullary disease and effusions are less common MM manifestations, especially at initial diagnosis.
Observation:
- Anaplastic myeloma (AMM) is a rare morphological variant of MM.
- AMM has a predisposition for extramedullary involvement.
- This report details a case of malignant plasmacytic ascites presenting at the onset of AMM.
Findings:
- Malignant plasmacytic ascites can be an initial presentation of anaplastic multiple myeloma.
- This finding underscores the potential for early extramedullary manifestation in AMM.
- The case illustrates a rare but significant clinical scenario in hematologic oncology.
Implications:
- Recognizing ascites at MM onset is crucial for timely diagnosis and treatment.
- This case expands the understanding of AMM's clinical spectrum.
- Further research into AMM's extramedullary potential may improve patient outcomes.
