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Concentric remodeling and the metabolic-associated steatotic liver disease in patients with type 1 diabetes: an

Klaudia Czarnik1, Zbigniew Sablik2, Anna Borkowska3

  • 1Department of Internal Diseases and Diabetology, Medical University of Lodz, Central Teaching Hospital in Lodz, 251 Pomorska Street, 92-213, Lodz, Poland. klaudia.czarnik@umed.lodz.pl.

Acta Diabetologica
|September 17, 2024
PubMed

Insights

In young patients with type 1 diabetes (T1D), a higher Fatty Liver Index (FLI) correlates with increased risk of left ventricle (LV) remodeling. This suggests FLI may help identify T1D patients needing closer cardiac monitoring.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Diabetic cardiomyopathy in type 1 diabetes (T1D) often presents as asymptomatic diastolic dysfunction and left ventricle (LV) remodeling.
  • The role of metabolic-associated steatotic liver disease (MASLD) in T1D-related cardiac remodeling is understudied.
  • This research investigates the link between MASLD risk and LV remodeling in young T1D patients without heart failure.

Purpose of the Study:

  • To determine the correlation between MASLD risk, assessed by Fatty Liver Index (FLI), and relative wall thickness (RWT) in young T1D patients.
  • To explore the association between FLI and LV remodeling indicators in T1D.
  • To identify potential predictors of cardiac remodeling in T1D.

Main Methods:

  • Recruitment of T1D patients from an inpatient diabetology department.
  • Collection of laboratory test results and echocardiographic data.
  • Estimation of MASLD risk using FLI and statistical analysis of acquired data.

Main Results:

  • The study included 55 T1D patients; 25 exhibited LV remodeling (RWT > 0.42).
  • Patients with LV remodeling had significantly higher FLI (40.97 vs. 13.82) and BMI (27.3 vs. 22.5).
  • FLI demonstrated a correlation with LV remodeling risk (OR 1.028, p=0.05), with an optimal predictive FLI cutoff of 26.38 for RWT > 0.42.

Conclusions:

  • Fatty Liver Index (FLI) is correlated with relative wall thickness (RWT) in T1D patients.
  • This association is independent of diabetes metabolic control.
  • FLI may serve as a valuable tool for identifying T1D patients at higher risk for left ventricle remodeling.
Abstract

Keywords:
Diabetes complicationsDiabetes type 1Left ventricle remodelingMetabolic-associated steatotic liver disease

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