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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Photonic crystal fiber (PCF) biosensors with surface plasmon resonance (SPR) show great potential for detecting various biological substances and contaminants. Optimizing structural parameters enhances their sensing capabilities for diverse applications.

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Area of Science:

Optoelectronics
Nanotechnology
Biomedical Engineering

Background:

Photonic crystal fibers (PCFs) offer unique light-confining properties.
Surface plasmon resonance (SPR) is a label-free detection technique highly sensitive to refractive index changes.
Conventional biosensors face limitations in sensitivity and specificity.

Purpose of the Study:

To provide a comprehensive overview of current and future advances in PCF-based biosensors.
To investigate the impact of structural parameter variations on phase matching conditions in PCF-SPR biosensors.
To highlight the advantages of PCF-SPR biosensors over conventional methods.

Main Methods:

Investigating the influence of structural parameters: pitch, air hole diameter, and gold layer thickness.
Reviewing recent studies on PCF biosensors for diverse applications.
Analyzing the fundamental principles and comparative benefits of PCF biosensors.

Main Results:

PCF-SPR biosensors can detect biological substances like glucose, pH, and serum proteins.
These sensors can identify bio-components in bodily fluids (urine, blood, saliva).
Detection of pathogens, bacteria, and contaminants in food, water, and air is feasible.

Conclusions:

Integration of SPR significantly enhances the sensing capabilities of PCF biosensors.
Optimizing structural parameters is crucial for improving phase matching conditions and sensing performance.
PCF-SPR biosensors are promising tools for diverse applications in the field of biosensing.