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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...

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Updated: Jun 12, 2025

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

Decoding recurrent pregnancy loss: insights from comparative proteomics studies.

Katarina Davalieva¹, Damjan Kocarev¹, Dijana Plaseska-Karanfilska¹

¹Research Centre for Genetic Engineering and Biotechnology "Georgi D Efremov", Macedonian Academy of Sciences and Arts, Krste Misirkov 2, 1000 Skopje, North Macedonia.

Biology of Reproduction

|September 17, 2024

Summary

Recurrent pregnancy loss (RPL) affects 2% of women, with unknown causes in over half of cases. Proteomic analysis offers insights into RPL pathogenesis and potential biomarkers.

Keywords:

biomarker proteomics recurrent pregnancy loss spontaneous abortion

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Last Updated: Jun 12, 2025

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Quantitative Analysis of Chromatin Proteomes in Disease

Quantitative Analysis of Chromatin Proteomes in Disease

Published on: December 28, 2012

Area of Science:

Reproductive Biology
Proteomics
Biomarker Discovery

Background:

Recurrent pregnancy loss (RPL) impacts up to 2% of women, leading to significant emotional and societal distress.
The underlying causes of RPL remain unidentified in over 50% of affected individuals.
Comparative proteomic analysis presents a promising avenue for elucidating RPL's complex pathogenesis.

Purpose of the Study:

To critically evaluate published comparative proteomic studies on human samples from women with RPL.
To consolidate findings on analyzed materials, proteomics platforms, and identified candidate biomarkers.
To present an overview of altered biological pathways and processes implicated in RPL.

Main Methods:

Systematic literature search of PubMed and Google Scholar databases.
Inclusion of comparative proteomic studies utilizing human samples from women with RPL.
Bioinformatics analysis of high-throughput proteomic data.

Main Results:

Detailed overview of diverse human sample types analyzed (e.g., chorionic villi, decidua, placenta, endometrium, maternal blood).
Identification and discussion of top candidate biomarkers and altered pathways associated with RPL.
Presentation of common biological processes and pathways implicated in RPL pathogenesis.

Conclusions:

Comparative proteomics has identified candidate biomarkers and altered pathways in RPL.
Further research is needed to translate these findings into diagnostic and therapeutic strategies.
Future directions focus on developing novel and effective treatments for RPL.