Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

61
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
61

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Barriers to Kidney Transplantation in the United States.

Journal of the American Society of Nephrology : JASN·2026
Same author

ASO Author Reflections: Mortality During the Real-World Adoption of Robotic Pancreaticoduodenectomy in the USA.

Annals of surgical oncology·2026
Same author

ASO Visual Abstract: Increased Mortality with Surgeon Adoption of Robotic Pancreaticoduodenectomy-A National EHR Study of Outcomes.

Annals of surgical oncology·2026
Same author

Largest Year-on-Year Decline in Deceased Donation in United States History.

Clinical transplantation·2026
Same author

Increased Mortality with Surgeon Adoption of Robotic Pancreaticoduodenectomy: A National EHR Study of Outcomes.

Annals of surgical oncology·2026
Same author

Trends in Pregnancy After Kidney Transplantation in the United States.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026

Related Experiment Video

Updated: Jun 12, 2025

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.1K

Diagnosing the Recent Decrease in Utilization of Deceased Donor Kidneys.

Nicholas L Wood1, Douglas N VanDerwerken2, Allan B Massie3

  • 1Hennepin Healthcare Research Institute, Minneapolis, MN.

Transplantation
|September 17, 2024
PubMed
Summary
This summary is machine-generated.

The kidney allocation system (KAS250) and increased use of nonideal donors are linked to higher kidney nonuse rates. Recovering more kidneys, even from nonideal donors, ultimately benefits patients needing transplants.

More Related Videos

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.1K
Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

11.8K

Related Experiment Videos

Last Updated: Jun 12, 2025

Using a Chemical Biopsy for Graft Quality Assessment
05:00

Using a Chemical Biopsy for Graft Quality Assessment

Published on: June 17, 2020

5.1K
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
08:12

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

Published on: July 15, 2015

19.1K
Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

11.8K

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Public Health Policy

Background:

  • Deceased donor kidney transplants are increasing but kidney nonuse has risen to 25.8% since the implementation of the KAS250.
  • The KAS250 system, based on 250-nautical-mile circles, may contribute to increased kidney nonuse.

Purpose of the Study:

  • To investigate the factors associated with the rising rate of nonuse of recovered deceased donor kidneys.
  • To evaluate the impact of the KAS250 system and the increasing recovery of nonideal donor kidneys on transplant outcomes.

Main Methods:

  • Analysis of Scientific Registry of Transplant Recipients data for deceased donor kidneys recovered between March 2019 and January 2023.
  • Calculation of the association between kidney nonuse and factors including donor characteristics, offer acceptance delays under KAS250, and COVID-19 impact.

Main Results:

  • Kidney nonuse increased from 21.2% pre-KAS250 to 25.8% post-KAS250.
  • Offer acceptance delays under KAS250 were associated with 33% of nonused kidneys; increased nonideal donors (donation after circulatory death, older donors, elevated creatinine) accounted for 43% of nonused kidneys.
  • An unexplained upward trend in nonuse was observed, while COVID-19's impact was not significant.

Conclusions:

  • The rise in kidney nonuse is significantly linked to KAS250 allocation complexity and delays, as well as increased recovery of nonideal donors.
  • Recovering more kidneys, including those from nonideal donors, is crucial for increasing kidney availability for patients awaiting transplantation.