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Updated: Jun 12, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Multiple sclerosis treatment underutilization predicts high risk for obstructive sleep apnea in patients with
John Patrick Dempsey1, Alexandra Balshi2, Andrew Bouley3
1Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Norton College of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.
Multiple Sclerosis and Related Disorders
|September 17, 2024
Summary
Patients with multiple sclerosis (MS) who underutilize disease-modifying therapies (DMTs) and experience fatigue have a higher risk of obstructive sleep apnea (OSA). Aggressive MS treatment may reduce OSA risk.
Area of Science:
- Neurology
- Sleep Medicine
- Immunology
Background:
- Obstructive sleep apnea (OSA) is more prevalent in multiple sclerosis (MS) patients than the general population.
- The link between MS treatment, disease activity, severity, fatigue, and OSA remains unclear.
Purpose of the Study:
- To investigate the associations between OSA risk, MS fatigue, and MS severity.
- To control for known OSA risk factors in the general population.
Main Methods:
- Administered OSA and fatigue questionnaires to MS patients.
- Collected demographic and clinical data.
- Used multivariate logistic regression to analyze relationships between OSA risk and MS disease severity.
Main Results:
- An inverse correlation was found between medication possession ratio (MPR) and high OSA risk.
- Fatigue and nonwhite race were positively correlated with high OSA risk.
- Models controlled for male sex, younger age, and BMI.
Conclusions:
- Underutilization of disease-modifying therapies (DMTs), fatigue, and nonwhite race predict high OSA risk in MS patients.
- Aggressive MS treatment is recommended to mitigate the risk of comorbid OSA and MS-related fatigue.
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