Related Experiment Video
Updated: Jun 12, 2025
08:02
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
5.4K
Closed-loop theranostic microgels for immune microenvironment modulation and microbiota remodeling in ulcerative
Zeyuan Jin1, Yaqi Zhang2, Haijun Hu1
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, China.
Biomaterials
|September 17, 2024
Summary
This study introduces novel theranostic microgels for ulcerative colitis, enabling simultaneous inflammation monitoring and precise treatment. These microgels effectively reduce inflammation and restore gut health, offering a new approach to inflammatory bowel disease management.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Gastroenterology
Background:
- Inflammatory bowel disease (IBD) involves increased reactive oxygen species (ROS) and gut dysbiosis.
- Current treatments for IBD focus on symptom management and drug overuse.
- A closed-loop strategy for in situ monitoring and precise IBD therapy is needed.
Purpose of the Study:
- To develop innovative 'cluster munition structure' theranostic microgels for ulcerative colitis.
- To integrate in situ monitoring and targeted therapy for IBD.
- To evaluate the efficacy of these microgels in an IBD model.
Main Methods:
- Designed theranostic microgels encapsulating a superoxide anion probe (TPC) and ROS-responsive nanogels with urolithin A (UA).
- Utilized alginate and ion-crosslinking to create the microgel structure.
- Assessed microgel performance in delivering TPC and UA to inflammatory sites for monitoring and treatment.
Main Results:
- Microgels triggered sequential release of TPC and UA at inflammatory sites.
- TPC-UA treatment significantly reduced inflammation, repaired colonic tissue, and remodeled gut microbiota.
- Chemiluminescence intensity correlated with inflammation levels, enabling monitoring during recovery.
Conclusions:
- Theranostic microgels demonstrated effective inflammation monitoring and precise therapy for ulcerative colitis.
- The 'cluster munition' design shows potential for improved inflammatory disease management.
- Restoration of epithelial tight junctions and gut microbiota balance were observed.
Keywords:
Inflammatory bowel diseaseOral administrationPostbioticsROS monitoringtheranostic microgelsMore Related Videos
Related Concept Videos
01:29Drugs for Treatment of Ulcerative Colitis in IBD
129
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
129
01:29Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:21Inflammatory Bowel Disease V: Surgical Management
128
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
128