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Immunohistochemical Expression of CXCL 10 in Vitiligo.

Asmaa Omar Abdelmonem1, Amany Mohammad Abdel-Latif2, Dareen Abdulaziz Mohamed2

  • 1Dermatology and Venereology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; and.

The American Journal of Dermatopathology
|September 17, 2024
PubMed
Summary
This summary is machine-generated.

Increased expression of Cysteine x cysteine motif chemokine ligand 10 (CXCL10) in vitiligo skin lesions suggests its role in disease pathogenesis. Active vitiligo showed significantly higher CXCL10 levels compared to stable vitiligo.

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Area of Science:

  • Dermatology
  • Immunology
  • Pathogenesis of autoimmune skin disorders

Background:

  • Vitiligo is an autoimmune skin condition causing melanocyte loss.
  • Cysteine x cysteine motif chemokine ligand 10 (CXCL10) is associated with Th1 responses and T-cell migration in inflammatory diseases.

Purpose of the Study:

  • To investigate the immunohistochemical (IHC) expression of CXCL10 in vitiligo skin lesions.
  • To explore the potential role of CXCL10 in the pathogenesis of vitiligo.

Main Methods:

  • A prospective, case-control study involving 20 vitiligo patients and 10 healthy controls.
  • Biopsies from lesional skin of stable vitiligo (n=10), active vitiligo (n=10), and controls were analyzed for CXCL10 IHC expression.

Main Results:

  • CXCL10 expression was detected in vitiligo lesions but absent in controls.
  • Mild to moderate CXCL10 expression was observed in stable vitiligo.
  • Strong CXCL10 expression was noted in active vitiligo, significantly higher than in stable vitiligo.

Conclusions:

  • Increased CXCL10 IHC expression in vitiligo lesions indicates its involvement in disease pathogenesis.
  • CXCL10 expression is significantly elevated in active vitiligo compared to stable vitiligo, suggesting a role in disease activity.