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Immunohistochemical Expression Of Cxcl 10 In Vitiligo.

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Immunohistochemical Expression Of Cxcl 10 In Vitiligo.

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Immunohistochemical Expression of CXCL 10 in Vitiligo.

Asmaa Omar Abdelmonem¹, Amany Mohammad Abdel-Latif², Dareen Abdulaziz Mohamed²

¹Dermatology and Venereology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; and.

The American Journal of Dermatopathology

|September 17, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Increased expression of Cysteine x cysteine motif chemokine ligand 10 (CXCL10) in vitiligo skin lesions suggests its role in disease pathogenesis. Active vitiligo showed significantly higher CXCL10 levels compared to stable vitiligo.

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Area of Science:

Dermatology
Immunology
Pathogenesis of autoimmune skin disorders

Background:

Vitiligo is an autoimmune skin condition causing melanocyte loss.
Cysteine x cysteine motif chemokine ligand 10 (CXCL10) is associated with Th1 responses and T-cell migration in inflammatory diseases.

Purpose of the Study:

To investigate the immunohistochemical (IHC) expression of CXCL10 in vitiligo skin lesions.
To explore the potential role of CXCL10 in the pathogenesis of vitiligo.

Main Methods:

A prospective, case-control study involving 20 vitiligo patients and 10 healthy controls.
Biopsies from lesional skin of stable vitiligo (n=10), active vitiligo (n=10), and controls were analyzed for CXCL10 IHC expression.

Main Results:

CXCL10 expression was detected in vitiligo lesions but absent in controls.
Mild to moderate CXCL10 expression was observed in stable vitiligo.
Strong CXCL10 expression was noted in active vitiligo, significantly higher than in stable vitiligo.

Conclusions:

Increased CXCL10 IHC expression in vitiligo lesions indicates its involvement in disease pathogenesis.
CXCL10 expression is significantly elevated in active vitiligo compared to stable vitiligo, suggesting a role in disease activity.