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Related Concept Videos

Human Genetics01:28

Human Genetics

542
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Genetic Screens02:46

Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Dementia01:30

Dementia

102
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Incomplete Dominance01:43

Incomplete Dominance

22.0K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: Jun 12, 2025

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

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Genetic testing in dementia.

Antoinette O'Connor1,2, Natalie S Ryan3,4, Christopher R S Belder3,5

  • 1Department of Neurology, Tallaght University Hospital, Dublin, Ireland aoconno6@tcd.ie.

Practical Neurology
|September 17, 2024
PubMed
Summary
This summary is machine-generated.

Genetic testing for dementia risk is becoming more common. Clinicians need guidance on requesting, consenting, and interpreting results for conditions like Alzheimer's disease and frontotemporal dementia.

Keywords:
ALZHEIMER-S DISEASEDEMENTIAGENETICS

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Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage
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The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
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Area of Science:

  • Neurology
  • Genetics
  • Cognitive Science

Background:

  • Increasing public concern about dementia risk.
  • Growing accessibility and integration of genetic testing into clinical practice.
  • Need for clinician education on genetic testing for cognitive disorders.

Purpose of the Study:

  • To outline an approach for genetic testing in cognitive clinics.
  • To guide clinicians in managing genetic testing for dementia.
  • To address the interpretation and communication of genetic results.

Main Methods:

  • Review of genetic testing protocols for dementia.
  • Discussion of clinical scenarios for genetic testing.
  • Guidance on patient consent and result communication.

Main Results:

  • Provides a framework for genetic testing in dementia.
  • Highlights key considerations for testing, consent, and interpretation.
  • Addresses specific dementia types: Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, and vascular cognitive impairment.

Conclusions:

  • Clinicians require updated knowledge for genetic testing in cognitive clinics.
  • A structured approach is essential for effective genetic testing and counseling in dementia care.
  • This guidance supports informed decision-making for patients and clinicians.