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Updated: Jun 12, 2025
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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
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Total-Body PET/CT: Pros and Cons.
Rodney J Hicks1, Robert E Ware2, Jason Callahan2
1The Melbourne Theranostic Innovation Centre, North Melbourne, Victoria 3051, Australia; St Vincent's Hospital, Department of Medicine, The University of Melbourne, Fitzroy, Victoria 3065, Australia.
Seminars in Nuclear Medicine
|September 17, 2024
Summary
Total-body PET/CT scanners, with extended fields of view (FOV), significantly enhance sensitivity for detecting annihilation events. This review examines the clinical and research applications of these advanced PET/CT devices.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Radiology
Background:
- Conventional PET/CT imaging involves sequential scanning, limiting efficiency for whole-body studies.
- Advancements in PET/CT technology have led to devices with extended axial fields of view (FOV).
Purpose of the Study:
- To review the advantages and disadvantages of total-body PET/CT devices.
- To discuss the clinical and research applications of total-body PET/CT imaging.
- To evaluate these systems from patient and institutional perspectives.
Main Methods:
- Review of existing literature and technological capabilities of total-body PET/CT scanners.
- Analysis of imaging sensitivity improvements with extended FOV.
- Discussion of patient throughput and institutional considerations.
Main Results:
- Total-body PET/CT devices, with FOVs of ~1m or ~2m, dramatically increase sensitivity for detecting annihilation events.
- Both sequential and true simultaneous total-body imaging approaches offer significant benefits over conventional methods.
- These devices present unique advantages and disadvantages for clinical and research use.
Conclusions:
- Total-body PET/CT imaging represents a significant advancement in sensitivity and efficiency for oncological and research studies.
- The adoption of total-body PET/CT requires careful consideration of its pros and cons in clinical and institutional settings.
- Further research and clinical implementation are warranted to fully leverage the potential of total-body PET/CT technology.
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