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Updated: Jun 12, 2025
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Published on: December 18, 2016
Temporal PLGG and epilepsy
Mony Benifla1, Shlomi Constantini2,3, Jonathan Roth2,3
1The Pediatric Neurosurgery Unit, Rambam Health Care Campus, Haifa, Israel. Benifla1@gmail.com.
Abstract:
Temporal lobe epilepsy in children is often secondary to various low-grade glial and glioneural tumors and rarely secondary to mesial temporal sclerosis. Despite the benign nature, tumor-associated TLE in children often becomes refractory over time. Abundant literature has shown the significant advantage of tumor resection compared to conservative treatment, in achieving seizure control, as well as the rates of antiseizure medication reduction. Despite these advantages, several considerations are to be related to when considering surgery. These include the impact of surgery on linguistic and neurocognitive development, especially at the younger age; the extent of resection and the role of ECoG; and the need for mesial temporal resection. Over recent years, traditional resection has been complemented with newer treatment options such as laser ablation and biological treatment, and these should be taken into account depending on the exact location and the ability to perform extensive resection in eloquent regions. In this overview manuscript, we discuss the various considerations treating tumor-associated pediatric temporal epilepsy.
Insights
Pediatric temporal lobe epilepsy (TLE) linked to tumors often becomes drug-resistant. Tumor resection offers significant seizure control benefits, but surgical decisions require careful consideration of developmental impacts and newer treatment options.
Area of Science:
- Pediatric Neurology
- Neurosurgery
- Epileptology
Background:
- Temporal lobe epilepsy (TLE) in children is frequently associated with low-grade glial and glioneuronal tumors.
- While tumors are often benign, the resulting TLE can become refractory to medication over time.
Purpose of the Study:
- To review the management considerations for tumor-associated pediatric temporal lobe epilepsy.
- To highlight the benefits of surgical intervention and discuss associated challenges.
Main Methods:
- Literature review of studies on surgical and conservative treatments for pediatric TLE secondary to tumors.
- Analysis of factors influencing surgical outcomes, including extent of resection and neurodevelopmental impact.
Main Results:
- Tumor resection demonstrates significant advantages over conservative management for seizure control and medication reduction in pediatric TLE.
- Surgical considerations include potential impacts on linguistic and neurocognitive development, especially in younger children.
Conclusions:
- Surgical resection is a key treatment for tumor-associated pediatric TLE, offering better seizure outcomes.
- Emerging treatments like laser ablation and biological therapies provide alternative or complementary options, particularly for tumors in eloquent brain regions.
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